Endothelial HSPA12B can inhibit inflammatory response under a variety of stress conditions, including lipopolysaccharide-induced sepsis,35 neuroinflammation,36 and sepsis-induced cardiomyopathy.34, 37 These findings suggest that HSPA12B may play a key role in suppressing inflammatory responses. The gene discussed is HSPA12B; the disease is cardiomyopathy.