Allosteric augmentation of mNMDARs, in principle, could improve synaptic regulation of mTORC1 and by doing so restore the normal balance of high- and low-efficiency mRNA translation in FXS.74,75 In a preliminary test of this hypothesis, we observed that Glyx-13, a positive modulator of NMDARs,55,76 corrected the protein synthesis phenotype in Fmr1 KO hippocampus. Here, FMR1 is linked to fragile X syndrome.