Interaction of NT-proBNP with adiponectin was significant for incident HF hospitalization; the association between adiponectin and HF events was significant only among participants with elevated NT-proBNP (HR: 1.60 [95% CI: 1.20-2.12] vs HR: 1.02 [95% CI: 0.60-1.73], P-interaction = 0.03). This evidence concerns the gene NPPB and hydrops fetalis.