When adjusting for traditional risk factors (age, sex, race/center, total cholesterol, HDL-C, current smoking, SBP, antihypertensive medication use, diabetes status, BMI, eGFR, lipid-lowering medication use, and log–hs-CRP; model 2), higher adiponectin level was significantly associated with increased risk for incident HF hospitalization (HR: 1.91; 95% CI: 1.49-2.44; P < 0.001 per natural-log unit increase in adiponectin), CVD death (HR: 1.67; 95% CI: 1.19-2.32; P = 0.003), and all-cause mortality (HR: 1.69; 95% CI: 1.41-2.04; P < 0.001) (Table 3). The gene discussed is ADIPOQ; the disease is diabetes mellitus.