In this substudy of STRONG-HF, the mean age was 63 ± 14 years, 39% were female, 77% White or Caucasian, 68% had LVEF ≤40%, and the median (Q1-Q3) NT-proBNP concentration was 2,868 (1,918-4,973) pg/mL at randomization (baseline). Here, NPPB is linked to hydrops fetalis.