The aim of this study was to investigate the effects ofquercetin on obesity and ovarian tissue by analyzing the expression of genesinvolved in the hypothalamus-pituitary-gonadal axis, includingob-Rb, ob-Ra, and brain-derived neurotrophic factor(Bdnf), neuropeptide Y (NPY), andKisspeptin (Kiss-1). This evidence concerns the gene RB1 and obesity due to melanocortin 4 receptor deficiency.