The network meta-analysis evaluated the effect of 21 interventions on stroke and all-cause mortality rates for the overall population: including ACEI, ARB, BB, CCB, conventional therapy, DI, non-BB, non-renin-angiotensin system inhibitors (non-RASI), renin inhibitors (RI), ACEI+BB, ACEI+CCB, ACEI+DI, ARB+ACEI, ARB+ACEI+BB, ARB+BB, ARB+CCB, ARB+DI, BB+DI, CCB+BB, CCB+DI, and placebo. This evidence concerns the gene REN and stroke disorder.