The NF-κB family of transcription factors comprises five subunits: RELA (RELA), RELB (RELB), c-REL (c-REL/REL), p105/p50 (NFKB1), and p100/p52 (NFKB2), which form active transcription factors through homo- or heterodimerization.8 Extensive research has concentrated on the canonical NF-κB family member, RELA, in the context of atherosclerosis, revealing its regulatory influence on vascular cell function, inflammation, and immunity.9,10 Mice with EC-specific deletion of RelA exhibit diminished atherosclerosis, underscoring its pivotal role in this disease. The gene discussed is NFKB2; the disease is atherosclerosis.