Following AAV-PCSK9 treatment and exposure to a western diet for 8 weeks to induce hypercholesterolaemia, c-RelECKO mice exhibited significantly smaller aortic atherosclerotic plaques compared to controls (Figure 6A), while plasma cholesterol and triglyceride levels remained unchanged (Figure 6B). The gene discussed is PCSK9; the disease is Hypercholesterolemia.