In addition, the focus on NLRP3 inflammasome activation via LPS and ATP stimulation leaves open the question of whether GA influences other activation pathways such as non-canonical or disease-specific activations (e.g. cholesterol crystals in atherosclerosis or lipid-induced activation in steatotic liver diseases) or other inflammasomes such as the absent in melanoma (AIM2) or NLR family CARD domain containing 4 (NLRC4) inflammasome. This evidence concerns the gene AIM2 and liver disorder.