In the literature, the impact of senescence in brain cells on cognition was reported in different murine models, including Tau-dependent [14] and AD [63] neurodegenerative disease models, after traumatic brain injury [18, 23], irradiation or chemotherapy [19, 28, 64] or in the context of aging [25, 31, 35, 36, 38, 49]. Here, MAPT is linked to neurodegenerative disease.