ANGPT2 and acute respiratory distress syndrome: Furthermore, other molecular markers such as plasma matrix metalloproteinase-3, soluble vascular endothelial growth factor receptor (sFlt-1), angiopoietin-2 (Ang-2), von Willebrand factor (vWF), and Clara cell secretory protein 16 (CC16) have also been linked to ARDS mortality prediction [31–34].