The most interesting differentially expressed cardiac genes are CACNA2D1, CASQ2, CDH2, DSC2, DSP, GJA5, GPD1L, KCNE3, LAMA4, MYOZ2, NEXN, SCN4B, SDHA, SLMAP and SNTA1, as mutations in these genes have been reported in ion channelopathies or cardiomyopathies [48, 49]. The gene discussed is CACNA2D1; the disease is cardiomyopathy.