Two top common variants in CDKN2B-AS1 and SIX6, thought to impact optic nerve vulnerability in POAG,31–33 were significantly associated with glaucoma risk in participants ≥63 years, but the risk did not vary significantly with age (Pinteraction ≥ 0.39; see Supplementary Table S10). Here, SIX6 is linked to glaucoma.