Integrins bind a wide range of cell adhesion and extracellular matrix molecules, and their outside-in signaling modulates the activation of several intracellular mediators including FAK, PI3K, AKT, mTOR, ERK, and JNK [111,112,113,114] as well as RHO-GTPases that are also involved in inside-out signaling and the regulation of the proliferation, differentiation and possibly chemosensitivity of malignant cells, including AML cells [111,115,116,117,118,119,120]. The gene discussed is PTK2; the disease is acute myeloid leukemia.