To summarize, our iron metabolic/ferroptotic clustering analysis based on these 16 differentially abundant proteins identified a heterogeneous minority of elderly patients with chemoresistant AML; these patients were heterogeneous both with regard to AML cell differentiation, CD34 expression, karyotype, FLT3-ITD, and NPM1-INS. Here, FLT3 is linked to acute myeloid leukemia.