Furthermore, four pairs were decreased in AML cells, and these are referred to as platelet-associated proteins (GP1BA and GP1BB), iron metabolism (transferrin and its receptor), cell cycle/histone regulation (CDK1, H1F0), and two members of the family structural maintenance of chromosomes (SMC) that modulate chromosome structure during mitosis (SMC2, SMC4). Here, GP1BB is linked to acute myeloid leukemia.