SMC4 and acute myeloid leukemia: Furthermore, four pairs were decreased in AML cells, and these are referred to as platelet-associated proteins (GP1BA and GP1BB), iron metabolism (transferrin and its receptor), cell cycle/histone regulation (CDK1, H1F0), and two members of the family structural maintenance of chromosomes (SMC) that modulate chromosome structure during mitosis (SMC2, SMC4).