Only ten biologically diverse proteins (five increased in AML and five in CD34+ cells) showed a marked differential expression, including myeloid differentiation markers (HBA1, HBB, PRG2, and possibly the antimicrobial PRGT); regulators of lipid (ALDH1A1, PLBD1), amino acid (PHGDH, possibly APCS), and iron (TF) metabolism; and transcriptional regulators (HIST1H1E, possibly APCS) (Table S6). The gene discussed is PLBD1; the disease is acute myeloid leukemia.