CXCR4 has been shown to assist melanoma metastatis to bones, and exosomes from those cells were able to cause the upregulation of CXCR7 a member of the CXCL12/CXCR4/CXCR7 signalling axis to promote them to a more osteotropic phenotype [267]. Here, ACKR3 is linked to melanoma.