Our RNA-Seqresults showed no change in CPT2 (data not shown).It has recently been reported that inactivation of sirtuin 3 (SIRT3) in platelets results in increased acetylation ofK79 in CPT2 and accumulation of acylcarnitines.40 As NAD+ (NADP+) depletion was also observedat the same time in this study, it may be necessary to consider abnormalacetylation of CPT2 as one of the mechanisms forthe abnormalities in β-oxidation identified in CLD. This evidence concerns the gene SIRT3 and congenital secretory chloride diarrhea 1.