DHEAS is anintermediatein the synthesis of sex hormones such as estrogen and testosterone.24 It has been reported that abnormalities in sexhormone metabolism are involved in the pathogenesis of NAFLD25 and that several hormone intermediates are reducedat serum levels with progressive fibrosis in NAFLD.26 This evidence concerns the gene SULT2A1 and metabolic dysfunction-associated steatotic liver disease.