Fujiwara et al. reported that acylcarnitineaccumulated in HCCtissues of mice treated with a high-fat diet plus DEN in a study usinga NASH mouse model and that carnitine palmitoyltransferase 2 (CPT2), which converts acylcarnitine to acyl-CoA, was downregulated.39 The accumulation of acylcarnitines are observednot only in tumor tissue but also in adjacent nontumor tissue, suggestingthat they play an important role in NASH-associated HCC. This evidence concerns the gene CPT2 and metabolic dysfunction-associated steatohepatitis.