A study on fibromyalgia (FM) demonstrated that disinhibition of the descending pain modulatory system (DPMS) is positively correlated with dysfunction in peripheral sensory neurons, as assessed by quantitative sensory testing (QST), and is inversely associated with serum levels of brain-derived neurotrophic factor (BDNF), highlighting the complex interplay between central and peripheral mechanisms in chronic pain [11]. This evidence concerns the gene BDNF and fibromyalgia.