HRS-AKI is defined as worsening renal function in patients with advanced cirrhosis that meets the ICA-AKI criteria, does not respond to volume expansion with albumin, has had no recent exposure to nephrotoxic agents, and no evidence of shock or signs of structural kidney disease, as defined by proteinuria (<500 mg/dL), hematuria (<50 red blood cells per high power field), and normal renal ultrasonographic findings [27]. The gene discussed is ALB; the disease is acute kidney injury.