ANXA1 and metastatic neoplasm: A post-translationally truncated version of Annexin A1 cleaved at Lys26 34 kDa in size localized to the caveolae of endothelium from multiple human and rat primary and metastatic tumors (i.e., breast, kidney, liver, lung, brain, and prostate), but not in normal tissue [9]; therefore, targets to Annexin A1 should not be present on the surface membrane of healthy cells unless there is damage to cells that caused externalization of the protein or if modifications have occurred to the targeting agent.