GATA2 deficiency presents a broad array of clinical manifestations, such as myelodysplastic syndrome/acute myeloid leukemia (MDS/AML), pulmonary alveolar proteinosis (PAP), congenital lymphedema, sensorineural hearing loss, viral warts, and skin cancers, including basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. This evidence concerns the gene GATA2 and melanoma.