GATA2 deficiency presents a broad array of clinical manifestations, such as myelodysplastic syndrome/acute myeloid leukemia (MDS/AML), pulmonary alveolar proteinosis (PAP), congenital lymphedema, sensorineural hearing loss, viral warts, and skin cancers, including basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. Here, GATA2 is linked to squamous cell carcinoma.