Clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 gene editing, immunoblotting, immunoprecipitation and cell‐based assays were used to characterise the role of Src homology region 2 domain‐containing phosphatase 2 (SHP2) in GIST. This evidence concerns the gene PTPN11 and gastrointestinal stromal tumor.