ACTH-stimulated aldosterone has demonstrated diagnostic utility in distinguishing primary from secondary adrenal insufficiency, as well as in the diagnosis of primary aldosteronism [26-28]. The increase in DHEA after ACTH stimulation was 2.43-fold, while the increase in DHEAS was marginal, suggesting that ACTH does not have an acute effect on the sulfation of DHEA. The gene discussed is POMC; the disease is Adrenal insufficiency.