The study's results revealed the negative impact of age on the clinical presentation of disease and tau protein deposition. The pattern of tau protein deposition was faster in younger individuals. High rates of tau accumulation were revealed in frontal and sensorimotor regions. Cortical atrophy and baseline volume correlated in the occipitoparietal areas. Higher atrophy rates and correlation with higher tau accumulation were revealed in the frontal and occipital lobes. Here, MAPT is linked to Cerebral cortical atrophy.