Similar results on distinct longitudinal spreading patterns for atrophy (more posterior) and tau uptake (more frontal) were observed in typical AD patients. Considering these geographical correlations between tau-PET uptake and atrophy is crucial, as it strengthens tau-PET's ability to predict neurodegeneration in specific brain regions, diagnostic impact, and development and assessment of future disease-modifying therapies [26]. This evidence concerns the gene MAPT and Alzheimer disease.