Abbreviations: ADAMTS13: disintegrin and metalloproteinase with thrombospondin motifs 13; CARS: compensatory anti-inflammatory response syndrome; CRP: C-reactive protein; DAMP: damage-associated molecular pattern; HLA-DR: human leukocyte antigen-DR Isotype. HMGB1: high mobility group box 1 protein; ICU: intensive care unit; IL: interleukin; MCP-1: monocyte chemoattractant protein-1; MODS: multiple organ dysfunction syndrome; mtDNA: mitochondrial DNA; SIRS: systemic inflammatory response syndrome; TEG: thromboelastography; TNF-α: tumor necrosis factor alpha. Here, HMGB1 is linked to systemic inflammatory response syndrome.