FBXL6 is overexpressed in various cancers and is correlated with the unfavorable prognosis of the disease, such as gastric cancer, colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma, etc. (Shi et al., 2020; Meng et al., 2023; Yu et al., 2022). The gene discussed is FBXL6; the disease is hereditary clear cell renal cell carcinoma.