Studies have indicated that SUV39H2 is typically overexpressed in cancer tissues, encompassing leukemia, lymphoma, lung cancer, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, etc., and the dysregulation of SUV39H2 contributes to carcinogenesis and participates in the invasion and metastasis of malignant tumors (Li et al., 2019; Schuhmacher et al., 2015). The gene discussed is SUV39H2; the disease is hepatocellular carcinoma.