,3 HIV-HBV coinfection is also associated with higher mortality compared with HIV alone, even for people who promptly initiate antiretroviral therapy (ART) and experience adequate CD4 T cell count recovery.4, 5, 6 In people with HIV-HBV coinfection, HBV DNA is associated with an increased risk of HCC and overall mortality; as such, HBV DNA suppression is an important therapeutic goal.7 Here, CD4 is linked to coinfection.