MKI67 and adenoma: Nonetheless, the Authors encourage its use as an additional prognostic information since a single case diagnosed as adenoma and classified as low-grade by the present study had a Ki67 of 25.37% which was considerably above the cut-off considered by both the authors of this study and Pereira et al. and developed metastasis after 198 days, pointing out that, in selected cases, Ki67 can provide useful prognostic information.