While LncRNA CAAlnc1 inhibits adipogenesis in C3H10T1/2 cells by binding to HuR and blocking the transcription of RRARγ and C/EBPα (Shen et al., 2019), lncRNA XIST inhibits high-fat diet-induced obesity by binding to C/EBPα (Wu et al., 2022). The gene discussed is CEBPA; the disease is Obesity.