While LncRNA CAAlnc1 inhibits adipogenesis in C3H10T1/2 cells by binding to HuR and blocking the transcription of RRARγ and C/EBPα (Shen et al., 2019), lncRNA XIST inhibits high-fat diet-induced obesity by binding to C/EBPα (Wu et al., 2022). Here, CEBPA is linked to obesity due to melanocortin 4 receptor deficiency.