According to the last update of the international WAO/EAACI guideline for the management of HAE “Sequencing of the SERPING1 gene can be supportive in the diagnostic workup of some HAE-C1-INH (including prenatal diagnosis); however, biochemical C1-INH testing is effective and less expensive than genetic” (15). This evidence concerns the gene SERPING1 and hereditary angioedema.