Given the hypothesized role of FH in RPE pathology during AMD progression, we confirmedthat RPE cells do express CFH mRNA (Supplementary Figure 1C), exhibit FH in protein lysates from both LR and HR iPSC-RPE cells (Figure 1M) and secretion of C3 (Supplementary Figure 1D). This evidence concerns the gene C3 and age-related macular degeneration.