CSCs immune evasion properties are influenced by humoral factors: TGFB1, a cytokine that induces immune suppression, EMT and stemness; IL-6, secreted by TAMs, that induces and maintains CSCs, signal transducer and activator of transcription 3 (STAT3), a transcription factor required for the maintenance of pluripotency in stem cells or Chemokine (C-C motif) ligand 20 (CCL20) and its receptor that recruits Tregs to promote tumor progression enhanced by immune evasion (34). Here, IL6 is linked to neoplasm.