CD8+ T and CD4+ T helper 1 cells are the most prominent anti-tumor T cells, instead, through the exocytosis of perforin and granzyme containing granules, the former, and secretion of high amounts of proinflammatory cytokines, such as interleukin-2 (IL-2), TNF-alpha, and interferon-gamma (IFNG), the latter, promote T cell priming activation, cytotoxic T lymphocytes (CTL) cytotoxicity, but also, the anti-tumoral activity of macrophages and NK cells (24). The gene discussed is TNF; the disease is neoplasm.