CHAC1 and squamous cell lung carcinoma: More in detail, ANXA3 in exosomes regulates negatively the ubiquitination of activating transcription factor 2 (ATF2), a transcription factor that induces ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1 (CHAC1) expression, thus blocking ferroptosis in lung squamous cell carcinoma (LSCC) cells (202).