CSCs form the primary tumor can favor the diffusion of pro-tumorigenic and proangiogenic factors such as VEGF-A, TGFB1, TNF-alpha and lysyl oxidase (LOX) that induce the expression of S100A (a Ca2+ binding protein involved in endothelial remodeling) in the metastatic area (2). The gene discussed is TGFB1; the disease is neoplasm.