IFNG and disease arising from reactivation of latent virus: However, in a study by Marin et al., they found an increase in the frequency of IFN-γ producing Th1 cells in LTBI, whereas IL-17 producing Th17 cells were more common in TB patients suggesting how Mtb alters the host profile towards the pathological Th17 response rather than the protective Th1 profile (91) In our previous study, we observed a progressive increase in IL-17 levels across the TB disease spectrum, ranging from latent infection to drug-resistant TB (DR-TB).