Interestingly, despite the previously documented favorable effects of CML-CNP on blood glucose balance (Sudirman et al., 2019), endothelial cell function (Sudirman et al., 2019), and lipid profile (Alqahtani et al., 2023), thrombocytosis was still found in the FTN + CML-CNP-treated rats. Here, CNP is linked to thrombocytosis disease.