Schwann cells, through secreting C-X-C motif chemokine ligand 5 (CXCL5), activate the PI3K/AKT/GSK-3β/Snail-Twist signaling pathway in lung cancer cells, mediates EMT, and increases the motility, invasiveness, and metastatic potential of lung cancer cells (Zhou et al., 2018). This evidence concerns the gene TWIST1 and lung cancer.