Vimentin is a key EMT biomarker present in mesenchymal cells and usually overexpressed during cancer metastasis (Usman et al., 2021), while MMP-2 and MMP-9 are peptidases involved in extracellular matrix remodeling and tumor invasive processes, favoring melanoma spreading and metastasis (Napoli et al., 2020). This evidence concerns the gene VIM and melanoma.