Skin involvement at diagnosis (OR 3.66, 95%CI, 1.06–12.62, p = 0.040), RF-positivity (OR 6.50, 95%CI, 1.32–31.91, p = 0.021), and presence of anti-TPO-Ab (OR 6.00, 95%CI, 1.17–30.62, p = 0.031), and Tg-Ab at diagnosis (OR 9.00, 95%CI 1.33–61.03, p = 0.024) were the clinical and laboratory factors which affected the prevalence of overweight and obesity in a univariate analysis (Table 3). This evidence concerns the gene TPO and obesity due to melanocortin 4 receptor deficiency.