Although this patient has not yet had a bone marrow biopsy, the high‐level somatic IDH2 and SRSF2 variants present in nearly all of her circulating white blood cells raise concern for the future development of a myeloid malignancy, such as a myelodysplastic neoplasm (previously myelodysplastic syndrome [MDS]) or acute myeloid leukemia [AML]). Here, SRSF2 is linked to acute myeloid leukemia.