SIRT6 and familial pancreatic carcinoma: MD simulations revealed that 11e binding induced significant conformational changes in SIRT6, and further free energy and community network analyses demonstrated that 11e binding disrupted internal signaling pathways, reducing SIRT6 deacetylase activity, thus presenting a novel approach for anti-pancreatic cancer therapy.100 Compound 8a was identified as a non-competitive inhibitor of SIRT6.101,102 Binding energy calculations confirmed the strong interaction between 8a and SIRT6, further supporting its inhibitory mechanism.102