HIF1A and cancer: In cancer biology, SIRT6 primarily acts as a tumor suppressor by inhibiting oncogenes such as c-Myc, HIF-1α, and c-Jun, modulating key signaling pathways like PI3K/Akt and MAPK/ERK, and inducing cell cycle arrest and apoptosis.95 However, the role of SIRT6 in cancer is highly complex and context-dependent, necessitating a deeper understanding of its regulation to develop targeted therapies.