The demonstrated phenotype is various in the patients with IGHD due to the underlying genetic defect and may pursue with other pituitary hormone deficiencies, considerably genetic disorders in transcription factors responsible for the Hypothalamus Pituitary axis development or in GH secretion pursue with a higher risk of additional pituitary endocrinopathies, which is about 5.5% in childhood‐onset and 35% in adulthood‐onset [19]. This evidence concerns the gene GH1 and isolated congenital growth hormone deficiency.