A 2024 analysis that pooled several large cohorts, including MESA, ARIC, Coronary Artery Risk Development in Young Adults (CARDIA), Jackson Heart Study (JHS), and Framingham Heart Study-Offspring (FHS-OS), encompassing 27,756 people, showed that higher Lp(a) levels are associated with an increased risk of ASCVD. The gene discussed is LPA; the disease is atherosclerosis.