For both EAO and LAO cancers, αSMA-high cancers had fewer CD4+ T cells/HPF than αSMA-low cancers (mean 2.1 vs 5.2 CD4+ TILs/HPF, P = 0.003; mean 4.3 vs 9.2 CD4+ TILs/HPF, P = 0.015, respectively; Figure 5E). This evidence concerns the gene ACTA1 and cancer.