VCAN and neoplasm: Upon proteolytic cleavage via ADAMTS (A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif) proteases, the N-terminal fragment of VCAN termed versikine (Vkine) is released, which has been associated with improved cDC1 dendritic cell (a subset of DC that has high capacity to present tumor antigens) maturation and activation and increased T-cell infiltration [20, 25, 26].