Previous studies showed that PlGF inhibition improves cirrhosis severity and liver function across different models.[23], [24], [25] Our study similarly found that deleting Plgf in rats attenuated CBDL-induced cirrhosis severity, as evidenced by reduced portal hypertension, decreased collagen deposition, and improved liver function in Plgf-deficient rats. This evidence concerns the gene PGF and portal hypertension.