In addition, in patients with Child-Pugh A cirrhosis, those with clinically significant portal hypertension with esophageal varices or portosystemic collaterals did not exhibit differences in PlGF levels compared with patients without these clinical features (30.9 ± 3.3 vs. 29.6 ± 3.1 pg/ml, respectively). This evidence concerns the gene PGF and portal hypertension.