This member of the vascular endothelial growth factor (VEGF) family is abundantly expressed in conditions affecting the liver and lungs.[22], [23], [24], [25] Blocking PlGF with antibodies has been shown to reduce IPVDs and hypoxemia in cirrhotic mice with HPS by modulating pulmonary inflammation and angiogenesis.22 The gene discussed is PGF; the disease is Hermansky-Pudlak syndrome.