Because these chemokines regulate the infiltration of CXCR3-expressing immune cells to sites of liver injury, they play a crucial role in various liver diseases, such as hepatitis C, metabolic dysfunction-associated steatohepatitis (MASH), and HCC.[8], [9], [10], [11] Nevertheless, the ability of HDV to promote chemokine expression changes in the liver of patients with CHD and the potential impact that such changes may have on liver-resident and infiltrating immune cells, in particular on CXCR3-expressing immune cells, are poorly defined. This evidence concerns the gene CXCR3 and metabolic dysfunction-associated steatohepatitis.