Liver-resident and auto-aggressive CD8 T cells have been highlighted as key players in MASH immunopathology,26 and even in CHB and CHD, liver-resident bystander CD8 T cells have been shown to correlate with liver inflammation.[27], [28], [29] Thus far, the activation and liver infiltration of Th1-polarised CD4 T cells has been reported for autoimmune hepatitis.30 This evidence concerns the gene CD4 and autoimmune hepatitis.