Similarly, MCL DAT-related FC may also offer potential insights into Alzheimer's disease pathological changes since MCL DAT reductions have been reported to be more severe than in the NST pathway13 and lower CSF levels of DAT have been associated with hypometabolism in the posterior DMN in Alzheimer's disease.57 This evidence concerns the gene SLC6A3 and early-onset autosomal dominant Alzheimer disease.