IL1B and Sepsis: Catechin significantly reduces the ROS levels in kidney tissue in a mouse sepsis model (one of the main factors contributing to kidney damage during sepsis), attenuates macrophage polarization towards the M1 phenotype and decreases proinflammatory cytokine (TNF-α, interleukins IL-1β and IL-6) in mice sepsis models and macrophage cell cultures (44).