Isolated hesperidin and hesperidin aglycone showed hepatic protection against non-alcoholic fatty liver disease (NAFLD) by decreasing the ROS and MDA values; increasing the antioxidant activity of SOD, glutathione peroxidase, glutamate-cysteine ligase catalytic subunit, glutathione reductase and heme oxygenase-1; and controlling liver inflammation through suppression of NF-κB activation (47). The gene discussed is HMOX1; the disease is metabolic dysfunction-associated steatotic liver disease.