ASPH and neoplasm: Research has shown that ASPH not only influences the prognosis of hepatocellular carcinoma under the regulation of inositol polyphosphate-5-phosphatase F (INPP5F) (30), but also promotes tumor progression and poor prognosis by activating Notch and PI3K-dependent signaling pathways, inducing a delay in tumor cell senescence and impairing mitochondrial integrity (31).