HOXB7 and HOXC6 were positively correlated with TMB in most cancers, and HOXB7 was strongly correlated with TMB in ACC, HNSC, PAAD, and STAD, and HOXC6 was strongly correlated with TMB in COAD, LGG, MESO, and PRAD (R>0.2, Figure 8A). Here, HOXC6 is linked to pancreatic adenocarcinoma.