CRP and colorectal carcinoma: In the future, it is expected that by optimizing the detection methods of C-reactive protein (CRP), unifying the detection cut-off values, focusing on optimizing the detection age for people aged 50 and above and shortening the follow-up intervals, and conducting stratified research fully considering gender differences, combined with multi-omics technologies to deeply explore its association with factors such as the gut microbiota, the risk of CRC can be accurately predicted, contributing to the formulation of personalized prevention and treatment strategies.