While the longitudinal study of 3,075 individuals aged 70-79 showed a correlation between TNF - α serum concentrations and cancer susceptibility and an increased occurrence of colorectal malignancies in those with high TNF - α levels (67), two nested case-control investigations failed to establish significant links between TNFR2 and CRC likelihood (28, 30). The gene discussed is TNFRSF1B; the disease is cancer.