Future research could focus on expanding sample sizes, thoroughly analyzing the differences in the role of IL-6 in different stages, locations (colon versus rectum), and ethnic populations of colorectal cancer, integrating multi-dimensional factors, and precisely elucidating its complex mechanisms with the aid of advanced technologies, so as to accurately transform IL-6 plasma levels into reliable indicators for the early detection and prognostic judgment of colorectal cancer, facilitating the implementation of personalized medicine. The gene discussed is IL6; the disease is colorectal cancer.