In a pioneering study, Alsbach and colleagues advanced the hypothesis that IFN-γ exerts an antitumor effect by impeding the proliferation of tumor cells, stimulating the activation of myeloid cells, promoting antigen presentation, and helping to clear tumor cells through the activation of tumor-specific immune responses, such as enhancing the cytotoxic activity of CD8+ T cells (91). This evidence concerns the gene IFNG and neoplasm.