FOXO1 and hepatocellular carcinoma: Additionally, HBXIP increases the phosphorylation level of FOXO1 protein by activating the PI3K/Akt pathway or upregulates miR-135a targeting the 3’ UTR of FOXO1 mRNA, leading to decreased transcriptional activity of FOXO1 and downregulation of PCK1 expression, thereby inhibiting gluconeogenesis and promoting tumor growth in HCC (130).