Additionally, HBXIP increases the phosphorylation level of FOXO1 protein by activating the PI3K/Akt pathway or upregulates miR-135a targeting the 3’ UTR of FOXO1 mRNA, leading to decreased transcriptional activity of FOXO1 and downregulation of PCK1 expression, thereby inhibiting gluconeogenesis and promoting tumor growth in HCC (130). This evidence concerns the gene PCK1 and neoplasm.