Mechanistically, METTL5 mediates the stabilization of c-Myc through a ubiquitin-specific peptidase 5 (USP5)-dependent deubiquitination process, further promoting the expression of glycolytic genes LDHA, ENO1, TPI1, SLC2A1, and PKM2, enhancing the Warburg effect while reducing OXPHOS, thus participating in the progression of HCC (89). The gene discussed is PKM; the disease is hepatocellular carcinoma.