Restoring PDSS2 expression may exert an anticancer effect by upregulating the expression of PDH, IDH, malate dehydrogenase 2 (MDH2), and CS in the Krebs cycle, and enhancing the activity of succinate dehydrogenase (SDH) and IDH, thereby inducing a metabolic shift in HCC from glycolysis to mitochondrial respiration (140). Here, MDH2 is linked to hepatocellular carcinoma.