(64, 65) revealed the utility of preoperative Gd-EOB-DTPA MRI radiomics models in predicting GPC3-positive expression and associated recurrence-free survival (RFS) in ≤ 5 cm hepatocellular carcinoma, signifying their potential as preoperative biomarkers for early recurrence in HCC patients devoid of major vascular invasion. The gene discussed is GPC3; the disease is hepatocellular carcinoma.